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A slice of John Wayne casserole on a black plate.

John Wayne Casserole

Chef Jenn
With a Bisquick base, the John Wayne Casserole is the perfect blend of beefy, cheesy, and spicy flavors!
4 from 1 vote
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Prep Time 15 minutes
Cook Time 35 minutes
Total Time 50 minutes
Course Main Course
Cuisine American
Servings 8
Calories 759 kcal

Ingredients
  

  • 3 cups bisquick
  • 1 cup water
  • 1 tablespoon cooking oil
  • 1 small onion diced
  • 1 pound ground beef
  • 2 teaspoons chili powder
  • 1 teaspoon onion powder
  • 1 teaspoon cumin
  • 1 teaspoon garlic powder
  • 1 bell pepper diced
  • 1 4-5 ounces can green chilis
  • 1 can Rotel tomatoes
  • 1 cup corn niblets
  • 1 cup tomatoes diced
  • ½ cup mayonnaise
  • 8 ounces cream cheese softened
  • 3 cups shredded cheddar divided

Instructions
 

  • Preheat your oven to 375-F and spray a 9x13-inch baking dish with nonstick cooking spray. Set this aside.
  • Combine the Bisquick mix with 1 cup of water in a large bowl. Mix until combined. Set aside.
  • Add the onions and cooking oil to a large skillet and cook over medium heat for 4-5 minutes or until the onion starts to soften.
  • Add the ground beef to the onions and continue to cook, breaking it up as it cooks. Drain off the fat.
  • Add the cumin, chili powder, garlic powder, onion powder, and a good pinch of salt and pepper to the ground beef and mix well. Cook for 2-3 minutes more, then transfer the beef mixture to a bowl and set aside
  • Combine the drained Rotel tomatoes, diced bell peppers, corn niblets, fresh tomatoes, and canned green chilies in the same skillet and mix well to combine. Heat over medium heat until heated through.
  • Combine the softened cream cheese, mayonnaise, and 2 cups of cheddar cheese in a bowl until well mixed.
  • Spread the Bisquick-water mixture into the bottom of your prepared baking dish. Use an offset spatula to help spread it around into an even layer.
  • Top with the ground beef mixture.
  • Top with the vegetable mixture.
  • Spread the cream cheese, mayo, and cheddar mixture over the top and finish by sprinkling the rest of the cheddar cheese over the top.
  • Bake at 375-F for about 30-35 minutes or until the baking mix has set on the bottom and the casserole is hot.

Video

Notes

Chef Jenn's Tips

  • You can use any ground meat in this recipe. Try it with ground turkey or chicken, or even sausage.
  • I love a dollop of sour cream on top - it adds a pop of freshness!
  • Don't hesitate to customize the spice levels to your liking. More chili powder or a dash of cayenne pepper can kick it up a notch.

Nutrition

Serving: 1cupCalories: 759kcalCarbohydrates: 40gProtein: 27gFat: 55gSaturated Fat: 22gPolyunsaturated Fat: 9gMonounsaturated Fat: 18gTrans Fat: 1gCholesterol: 118mgSodium: 1150mgPotassium: 478mgFiber: 3gSugar: 9gVitamin A: 1663IUVitamin C: 30mgCalcium: 438mgIron: 3mg

A Note on Nutritional Information

Nutritional information for this recipe is provided as a courtesy and is calculated based on available online ingredient information. It is only an approximate value. The accuracy of the nutritional information for any recipe on this site cannot be guaranteed.

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